The NALM-6 mannequin, a invaluable software in preclinical leukemia analysis, entails the implantation of human acute lymphoblastic leukemia cells into immunodeficient mice. This creates a residing system that mirrors the development and response to remedy seen in human leukemia, permitting researchers to review the illness and take a look at potential therapies in a extra managed atmosphere.
This mannequin’s growth offered researchers with a vital platform for testing new therapies and learning leukemia growth. It permits for detailed evaluation of illness development, drug resistance mechanisms, and the interplay between leukemia cells and the microenvironment. The flexibility to check potential therapies in vivo earlier than scientific trials gives a extra environment friendly and moral method to drug growth, contributing to the development of leukemia remedy.